Role of Professional Continuous Glucose Monitoring in the Management of Diabetes with High Glycemic Variability: A Cross-Sectional Study

Abstract

Continuous Glucose Monitoring (CGM) systems, a promising technology for frequent blood glucose level monitoring and detection of hyperglycemic and hypoglycemic excursions, were evaluated in a cross-sectional study involving 30 diabetes patients with high glycemic variability. Using the iPro2 professional CGM system, baseline fasting and postprandial blood glucose levels were obtained and patients were monitored over 3-5 days. Post-CGM data analysis led to modifications in the patient’s diet, physical activity, and insulin regimen, with follow-up assessments conducted after 2 months. The study, which eventually included 17 type 1, 8 type 2, and 5 gestational diabetes patients due to data recording issues, observed significant improvements in mean fasting blood glucose and HbA1C levels in all patients post-CGM-guided therapy modifications. However, the improvement in mean postprandial blood glucose was not statistically significant. The CGM also detected postprandial hyperglycemia and asymptomatic hypoglycemia, proving its value in managing diabetes with high glycemic variability and potentially preventing long-term complications.