Hemodynamic stability of each intubating dose of rocuronium and cisatracurium in adults undergoing elective surgeries under general anaesthesia

Abstract

It is worthwhile to note that the comparative clinical profile of rocuronium and cisatracurium are
reported in less number. Armed with evidences of safety profile of these two drugs, we decided to find
out if exceeding of the standard induction doses provides more favorable conditions for intubation. The
proposed study was conducted on 90 patients who underwent elective surgeries under general
anaesthesia the Department of Anaesthesiology, after obtaining ethical committee clearance. After taking
written informed consent, 90 patients aged between 20 to 60 years belonging to ASA grade I and ASA
grade II of either sex, undergoing elective surgery under general anaesthesia were included in the study.
They were randomly divided into 3 groups of 30 patients each, who received one of the muscle relaxant
for intubation. There are no dose-related effects on the incidence of changes from baseline (30% or
greater) in mean arterial blood pressure or heart rate associated with rocuronium bromide administration
over the dose range of 0.12 to 1.2 mg/kg (4 x ED95) within 5 minutes after rocuronium bromide
administration and prior to intubation