A Study of corrected QT interval in Asymptomatic type 2 Diabetes Mellitus patients.

Abstract

Introduction – Diabetes mellitus is a medical condition characterized by insufficient regulation of glucose levels in the blood. It is caused by abnormalities in the secretion of insulin, the action of insulin, or both, leading to a range of metabolic diseases. Cardiovascular diseases are frequent long-term consequence of type 2 diabetic mellitus (T2DM). The corrected QT interval is a reliable measure of the time it takes, for the ventricular myocardium to depolarize and repolarize. The aim of present study was to assess the corrected QT interval in asymptomatic type 2 Diabetes Mellitus patients.
Material and methods- The present prospective cross-sectional study was conducted at a B.J. Medical College, Ahmedabad and 200 asymptomatic diabetes mellitus patients were subjected to study. All the laboratory and clinical parameters were noted. ECG of patients were done according to protocol and corrected QT interval was measured.
Results – The mean age of patients was 53.9±10.8 years. The number of female patients (60%) was higher in number as compared to male (40%). The mean value of HbA1c (%) among patients was 9.50±3.25 and mean value of corrected QT interval (ms) was 493.48 ± 67.4. 35% of patients had prolonged corrected QT interval in ECG whereas 65% had normal ECG. Several factors were found to be significantly associated with an increased odds of prolonged corrected QT interval (p<0.05).
Conclusion-Abnormalities in the resting corrected QT interval in patients with type 2 diabetes mellitus (T2DM) suggest the beginning of cardiovascular alterations that worsen as the duration of the disease rises. Regular surveillance of individuals with T2DM using ECG can aid in the prompt identification of cardiovascular diseases.