“Pharmacological Evaluation of Anti-arthiritic activity of Euphorbia hirta Plant Extract on Rats”

Abstract

Euphorbia hirta is of the family Euphorbiaceae, owning various pharmacological properties like antiinflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic diseasethat can be
characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage. Objective of
the study is to assess the anti-arthritic activity of methanolic extract of Euphorbia hirta. Freund’s
complete adjuvant induced arthritic Model was followed for the evaluation. 0.1 mL of the FCA by intraplanar
injection was used to induce arthritis in Wistar rats. Methanolic extract (100 and 200 mg/kg) of Euphorbia
hirta were given to Wistar rats. Euphorbia hirta extract showed significant anti-arthritic activity in a dosedependent manner. However, Euphorbia hirta extract (200mg/kg) showed potential anti-arthritic activity.
From the study, it can be concluded that Euphorbia hirta possesses marked anti-arthriticactivity.