The relation between CYP2C9 gene polymorphism and warfarin dosing in an Iranian population

Abstract

Warfarin is a common anticoagulant agent which is widely used in many countries. However, Warfarin is one of those drugs which requires close monitoring and dosing while inappropriate could lead to hemorrhagic epoxides. Achieving a desirable international normalized ratio (INR) range depends on various demographic factors and genetic factors are now becoming an emerging area of interest in cardiovascular research. CYP2C9 is a gene encoding a member of cytochrome P450 enzyme which metabolizes many drugs. Genetic variation in this gene has been linked to abruption in Warfarin drug response. In present study the effect of genetic polymorphisms in CYP2C9 gene and its response to Warfarin is investigated.