Role of Atherogenic Indices and Association of LPL Intron 6 (C >T) Gene Polymorphism with Dyslipidemia Subtypes in the Prediction of Cardiovascular Risk

Abstract

Background and Objectives: Dyslipidemia is renowned as a prominent risk factor for development of atherosclerosis and other Cardiovascular disease. The Aim study to estimation of lipid profile and predict the cardiovascular risk among the dyslipidemia subtypes and also determine the association of LPL intron 6 C >T (rs285) gene Polymorphism in dyslipidemia subtypes. Methods: A total number of 258 subjects were participated in our study, in which 129 members were with elevated lipid profile considered as cases and 129 numbers with normal lipids considered as control subjects. Among the 129 cases, they are further divided into dyslipidemia subtypes. All the sample were further used for analysis of lipid profile and determined the gene Polymorphism by RFLP. Results: In our study observed, elevated levels of lipid profile [TC (241.53±6.45), TGs (295.40±28.31), LDL-c (143.69±7.05), VLDL-c (59.08±5.66) and lower levels of HDL-c (39.70± 1.23) and higher values atherogenic indices in combined lipidemia type than the other types and controls. In genotype analysis was not showed significant association of intron 6 C >T gene polymorphisma in both hypercholesterolemia [odd’s ratio: 0.77(0.33-1.79); 0.18(0.05-0.62); χ2  p: 0.025] and hyperlipidemia [odd’s ratio: 0.40 (0.14-1.12); 0.82 (0.33-2.03); χ2  p: 0.177] cases compared with control subjects. But observed, higher risk with CT and CC genotypes in both hypertriglyceridemia and combined dyslipidemia cases. In combined lipidema cases the comparison of lipid profile of genotypes, CC genotypes showed significantly elevated triglycrides (349.5±39.49; p<0.05) and VLDL-c (69.91±7.898; p<0.05) than CT genotypes. Conclusion: Combined lipidemia is one of the major forms of dyslipidemia and atherogenic indices are used as strong predictors to assess the cardiovascular risk in the clinical practices. In case genotype analysis, LPL intron 6 C >T gene Polymorphism may be associated with elevated levels of triglycrdies and VLDL-c.