A PROSPECTIVE STUDY OF FASTING AND POSTPRANDIAL LIPID ABNORMALITIES IN TYPE 2 DIABETES MELLITUS

Abstract

Type 2 diabetes mellitus (DM) is characterized by insulin resistance; a syndrome which includes glucose intolerance, dyslipidemia, and hypertension, and results in an increased predisposition to atherosclerotic vascular disease. The increased prevalence of cardiovascular disability in type 2 DM is believed to be because of a prolonged and exaggerated postprandial dysmetabolism, most notably hyperglycemia and hypertriglyceridemia, which induce endothelial dysfunction and oxidative stress. Materials and Methods: Assessment of fasting and postprandial lipid abnormalities in type 2 diabetes mellitus was done. A case control study was conducted in the OPD of Department of General Medicine, Maheshwara Medical College, Chitkul(v), Isnapur x road, pattancheruvu, sangareddy (dist). This study was carried out on 100 known cases of type-2 Diabetes Mellitus visiting at General Medicine, Maheshwara Medical College, OPD on regular basis were included as cases; based on non-probability purposive sampling technique and 100 healthy participants who were not known cases of type-2 Diabetes Mellitus were included in the study as controls. Results: A total of 100 controls and 100 cases were included in the final analysis. Table I shows the baseline characteristics of patients with type 2 diabetes mellitus. Diabetic subjects were middle aged (mean age 45.1±7.47 years), with a mean body mass index (BMI) of 25.67±5.02 kg/sq m. Diabetic subjects were matched for age, BMI with controls, Family history of diabetes. Conclusion: Both fasting and post prandial lipid abnormalities seen in type 2 diabetes but the post-prandial lipid profile was altered when compare to fasting lipid levels. Lifestyle modifications along with diet and proper lipid lowering drugs are helpful in diabetic individuals with lipid abnormalities.