"Predictors of Failure and Bleeding in Intrapleural Fibrinolytic Therapy for Loculated Pleural Effusions: A Cohort Study"

Abstract

Loculated pleural effusion (LPE) is a complex and challenging clinical condition resulting from pleural infection or inflammation, often leading to fibrin deposition and formation of septations within the pleural cavity. LPE commonly arises in the context of complicated parapneumonic effusions, empyema, malignancy, and post-surgical states. The presence of loculations impairs the drainage of pleural fluid, leading to persistent symptoms, increased infection risk, and compromised respiratory function