Exploring Lactic Acid as a Novel Endodontic Irrigant: Enhancing Stem Cell Viability and Growth Factor Efficacy in Regenerative Endodontics

Abstract

Background:
Regenerative endodontic treatments (REPs) represent a paradigm shift in the treatment of juvenile teeth with necrotic pulp by facilitating tissue regeneration within the root canal system. This comprises an interplay of mesenchymal stem cells (MSCs), growth factors, and a biocompatible scaffold(5,14). A fundamental feature of REPs is the use of irrigants that not only disinfect the root 
canal but also protect MSC viability and trigger the release of bioactive chemicals, such as transforming growth factor-beta 1 (TGF-β1), to promote cell proliferation and differentiation(3,5)