The Role Of Tobacco In Carcinogenesis: Exploring The Link Between Nicotine And Cancer

Abstract

Tobacco smoking remains a major preventable cause of mortality worldwide and has emerged as a possible contributor to carcinogenesis, and nicotine is a possible contributor to carcinogenesis. Nicotine is also known for being addictive and has been shown to cause oxidative stress, inflammation, and activation of carcinogenic pathways, all of which are known to help tumour grow and spread. In this study, the biochemical, molecular, and physiological roles of nicotine in cancer development were assessed, and dose-dependent relationships and individual variability in nicotine metabolism were examined