EXPLOITATION OF SURFACTANT SELF-ASSEMBLY FOR PREPARING UREASE ENCAPSULATED ALGINATE NANOGELS

Abstract

In biomedical applications, alginate nanoparticles and micro particles cross - linked with Ca+2 particles is widespread. We utilise microemulsion polymerization to make alginate nanoparticles (nanogels) with various linking ions (Sr+2, Ba+2, Ca+2) to encapsulating urease enzyme as a model protein (jackbeans). Dispersion droplets demonstrated good stability and narrow, monomodal ranges with radii of 65 ± 10 nm when alginate quantities in the aqueous phase were 0.2 wt percent. The size of the nanogel is determined by the linking cation's affinity for the straight alginate chain's mannuronate and guluronate time in deciding units. Spectrometer X-ray
spectroscopy, dynamic light bouncing ensemble particle radii of nano alginate particles, scanning electron microscopy and zeta potential were characterize the surface charge and physical stability of the nanogels. Ba-alginate can be utilised as an alternative matrix for nano-encapsulation of molecules and in biological applications, according to this study and its shows better stability and
high surface charge . Generally divalent cations are cross-linked for the development of suitable alginate gels for different applications like BUN kit development ,therapeutics.