THE ROLE OF MICROBIOME IN CHRONIC RHINOSINUSITIS: IMPLICATIONS FOR PERSONALIZED TREARTMENT

Abstract

Chronic rhinosinusitis (CRS) is a long-standing inflammation of nasal and sinus mucosa, which negatively impacts patient’s quality of life. The recent research emphasize the central position of the microbiome in CRS with focus on microbial dysbiosis, meaning an upheaval of the normal bacterial flora, which erroneously fuels immune system chaos and inflammation. In CRS, pathogens like Staphylococcus aureus and Pseudomonas aeruginosa are found that replace normal flora and cause chronic symptoms.