Role of nitric oxide (NO) : Unveiling new horizons in changes of glaucoma vasculature and ocular surface among Primary Open Angle Glaucoma

Abstract

Objective: This article reviews the role of NO in POAG against the background of the vascular changes in  eye and ocular surface abnormalities. NO not only plays a significant role in regulation of IOP among glaucoma patients by influencing the outflow pathways but also plays a key role in vaso regulation of optic nerve & its effects on corneal surface to modulate the disease process .The aim of this study is to alert readers to possible NO involvement in glaucoma pathophysiology and encourage them to recognize possible therapeutic relevance.