TO EVALUATE THE EFFECTIVENESS OF SALIVARY UREA & CREATININE LEVELS AS A DIAGNOSTIC MARKER FOR CHRONIC KIDNEY DISEASE

Abstract

Background: Chronic kidney disease (CKD) is defined as kidney failure with the 
organ functions reduced or lost completely and the kidneys are incapable of filtering 
excess fluids. CKD leads to many metabolic changes in blood that often warrants 
frequent biochemical analysis. Estimation in blood is an invasive and worrisome 
procedure. It would be quite easier if a noninvasive alternative to blood analysis is 
identified. Saliva can be collected noninvasively, repeatedly, and without the help of 
healthcare personnel. 
Objective: This study analyses saliva as a medium to measure urea and creatinine 
levels in Chronic kidney disease(CKD) patients.The main objective of this study was to 
compare serum and salivary urea and creatinine levels in CKD patients and healthy 
controls, and to decide whether salivary creatinine and urea levels can be used to 
diagnose or monitor CKD in as efficiently as serum creatinine and urea levels.