A comparative study regarding serum cortisol concentration before and after administration of Etomidate as inducing agent in abdominal surgeries .
DOI:
https://doi.org/10.48047/Keywords:
etomidate, general anaesthesia, serum cortisol, post-operative nausea and vomiting.Abstract
Introduction
Etomidate,a hypnotic agent, a carboxylated imidazole, activates GABA-A receptor
containing B2 and B3 subunits, without analgesic activity. It is used as intravenous induction
agent for general anaesthesia. The drug etomidate causes temporary inhibition of steroid
synthesis after dose and infusion owing to its lack of effect on sympathetic nervous system
and on baroreceptor, haemodynamic stability after administration of injection etomidate is
observed. Etomidate is a short acting agent with rapid onset and recovery, good
cardiovascular stability and so it is an acceptable induction agent for patients with poor
cardiac functions. It causes primary adrenal cortical suppression by inhibiting 11-beta
hydroxylase, the enzyme important for adrenal steroid production.
Aims and Objectives
The study is aimed to estimate the serum cortisol concentration before and after
administration of inducing agent etomidate and its comparison and also to find out the side
effects of etomidate like post-operative nausea and vomiting, myoclonic movements, pain at
injection site, etc.
