Otorhinolaryngological Manifestations of Laryngopharyngeal Reflux Disease and Role of Proton-Pump Inhibitors in its Management

Abstract

Background: Laryngopharyngeal reflux Disease (LPRD) is defined as the retrograde flow of 
stomach content into the larynx and pharynx whereby this content comes in contact with the 
upper aerodigestive tract. It is an extraoesophageal variant of gastroesophageal reflux disease 
that affects the larynx and pharynx. Our study is aimed to evaluate symptoms and signs of 
Laryngopharyngeal Reflux Disease [LPRD] in the rural area and role of protonpump 
inhibitors in its management. Material and Methods: This is a prospective clinical 
observational study conducted in 50 patients diagnosed as LPRD on the basis of reflux 
finding score and reflux symptom index and to evaluate the role of PPI in LPR management 
by observing the effect of PPI on reflux finding score (RFS) and reflux symptom index (RFI) 
during the follow up period of 12 weeks in the department of Otorhinolaryngology in 
Kamineni Institute of Medical Sciences, Narketpally from November 2020 to November 
2022. Results: 76% of patients showed good response to the treatment and 24% had poor 
response. Conclusion: LPR was found to be predominant in females irrespective of age 
except in 6th decade where male predominance is seen.