FORMULATION AND ASSESSMENT OF ALBUMIN MICROSPHERES LOADED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Abstract

This study focuses on the formulation and evaluation of albumin microspheres encapsulating
non-steroidal anti-inflammatory drugs (NSAIDs). The goal is to enhance the therapeutic
efficacy and reduce the side effects associated with NSAIDs. Albumin, a natural protein, was
chosen for its biocompatibility, biodegradability, and non-immunogenic properties, making it
an ideal carrier for drug delivery systems. The microspheres were prepared using an emulsion
solvent evaporation technique, optimizing various parameters such as polymer concentration,
drug-to-polymer ratio, and emulsifier type and concentration. Characterization of the
microspheres included particle size analysis, surface morphology, drug loading efficiency,
and in vitro drug release studies. DSC, CDR & UV Spectral analysis was used to assess the
surface and shape of the microspheres, revealing a spherical structure with a smooth surface.
The drug loading efficiency was determined using spectrophotometric methods,
demonstrating high encapsulation efficiency. In vitro release studies were conducted in
simulated gastrointestinal fluids to mimic the drug release profile in the human body. The
release kinetics were analyzed using various mathematical models to understand the
mechanism of drug release. The formulated albumin microspheres showed a controlled and
sustained release of NSAIDs, reducing the frequency of dosing and potentially improving
patient compliance. Cytotoxicity studies indicated that the microspheres were non-toxic and
safe for use. This research highlights the potential of albumin microspheres as an effective
drug delivery system for NSAIDs, offering a promising approach to improving the
therapeutic outcomes and minimizing the adverse effects associated with these drugs.