AUTOLOGOUS SERUM SKIN TEST IN CHRONIC IDIOPATHIC URTICARIA

Abstract

Aim: The present study is undertaken to study positivity of autologous serum skin test
in patients suffering with chronic idiopathic urticaria
Methodology: This is an experimental study. In the present study 100 clinically
diagnosed cases of Chronic Idiopathic Urticaria attending the Department of
Dermatology, Venereology & Leprosy at KIMS, Narketpally were taken. The study
period was from 2019 December - 2020 August.
Results: A total number of 100 cases of chronic idiopathic urticaria reporting to the
Dermatology Venereology Leprology department, Osmania General Hospital were
studied. 46 of them were females and 54 were males. Maximum cases were in the age
group of 21-30 years (33%), followed by age group 31- 40 years (26%). The age of the
youngest patient was 14 years and that of the oldest was 65 years. Autoantibodies,
detected by ASST, were seen in the sera of 43% patients with CIU, comparable to
available reports in literature. Presence of autoantibodies was unrelated to gender and
the mean age of onset of the disease was earlier in ASST positive patients. Presence of
these autoantibodies was significantly associated with more duration of disease, more
duration of wheal, frequent attacks of disease and UAS > 5. Angioedema and
Abnormal Thyroid profile were significant in ASST positive patients. There was
difference in presentation of clinical symptoms between ASST positive and negative
patients but these were not statistically significant. There was difference in CBP, AEC,
ESR, RBS Sr IgE Levels and ANA between positive and negative ASST patients, but
these results were statistically insignificant.
Conclusion: Positive autologous serum skin test was seen in 60% of patients. It is a
simple, practicable in-vivo intradermal clinical test to differentiate chronic idiopathic
urticaria from autoimmune urticaria