A Comparative Study of Dexmedetomidine and Clonidine on Haemodynamic Changes During Tracheal Intubation

Abstract

Aim and objectives:
1) To compare the effect of dexmedetomidine and clonidine on haemodynamic changes
during Laryngoscopy and tracheal intubation.
2)To evaluate the effects of dexmedetomidine and clonidine on haemodynamic changes
during Laryngoscopy and tracheal intubation.
3) To compare the side effects.
Materials & Methods
After approval of the institutional ethical committee, this prospective observational study was
conducted on 60 patients of ASA Grade I & II , undergoing elective surgeries under general
anesthesia.
Group A : injection Dexmedetomidine 0.5mcg/kg diluted to 20ml with normal saline were given
over 10 minutes.
Group B injection. Clonidine 1mcg/kg diluted to 20ml with normal saline were given over 10
minutes.
All patient received Injection Pentazocine 0.3mg/kg and were pre-oxygenated for 3minute
Anaesthesia was induced with thiopantone sodium (5mg/kg intravenous) till loss of eyelashreflex
over 30 second and mask ventilation was confirmed. Injection succhinylcholine 1.5mg/kg was
given to facilitate laryngoscopy and intubation. anaesthesia was maintained with oxygen nitrous
oxide ,halothane with intermittent use of injection Atracurium and controlled ventilation.
At the end of surgery the neuromuscular blockade was antagonized with injection Glycopyrolate
(.01mg/kg) Intravenous .and injection Neostigmine(.05mg/kg)i.v. and patient were extubated.
Result
Dexmedetomidine is more effective than Clonidine in attenuation of haemodynamic changes
during laryngoscopy and intubation