Preemptive Analgesic Effects and Effects on Hemodynamic Parameters of Intravenous Paracetamol in Abdominal Surgeries-A Multicentre Comparative Study
DOI:
https://doi.org/10.48047/Keywords:
Preemptive, Analgesic, hemodynamic, Intravenous,Paracetamol&Abdominal.Abstract
Background & Method: The present study entitled “preemptive analgesic effects of
intravenous paracetamol in abdominal surgeries” was undertaken in the department of
anesthesiology in the four different associated hospitals across India in the similar study
duration with equal number of sample size from each hospital. The study involves
observations on 80 patients (20 from each hospital , 10 in the cases group and 10 in the
control group) of ASA grade I and II between age group 20-60 years, scheduled to undergo
abdominal surgery under general anesthesia.
Result:Pre-induction period the mean pulse was comparable in either groups. Post-induction,
3 minutes after of induction of anesthesia, mean pulse in paracetamol group was lower
compared to control and the value was statistically significant P<0.05.Mean Arterial Pressure
(MAP) at different time intervals during the procedure.The MAP was lower post intubation
up-to 10 minutes as seen by mean values which were statistically significant (P<0.05). MAP
at 5 min and 10 min post intubation were 0.011 and 0.049 respectively.After 10 minutes not
much statistically significant difference was seen ( P>0.05) and MAP was comparable.
Conclusion:The findings of present clinical retrospective observational study allow us to
conclude that one gram paracetamol when given pre-emptively provided hemodynamic
stability and had better pain scores.
