Study of Correlation between Dyslipidemia with Meibomian Gland Dysfunction and its Severity
DOI:
https://doi.org/10.48047/Keywords:
Symptomatic MGD, Dyslipidemia, OSDI, Lipid parameters.Abstract
Purpose: This study aimed to determine correlation between Dyslipidemia with
meibomian gland dysfunction (MGD) and its severity. The dyslipidemia of cases were
compared with the age and sex matched non-MGD individuals.
Materials and methods: This hospital based cross-sectional study was conducted in the
ophthalmology department of a tertiary hospital consisting of 188 patients (94 patients with
MGD and 94 controls without MGD). All the patients underwent comprehensive ocular
examination including visual acuity, slit lamp examination, intraocular pressure. Slit lamp
examination was performed to look for lid margin signs. Meibomian gland functionality was
assessed by fluorescein staining. The disease severity was assessed according to International
Workshop on Meibomian Gland Dysfunction and management 2011. MGD is divided into
four stages taking both symptoms and signs into consideration and eye with more grading of
MGD was included in study. Controls were age and sex matched non-MGD patient with
refractive error. Dyslipidemia was defined by TC ≥200 mg/dl, TGs ≥150 mg/dl, LDL-C ≥130
mg/dl and/or HDL-C <40 mg/dl. Lipid parameters were assessed for both cases and controls.
Data analysis was done by Statistical Package for Social Sciences (SPSS) version 17.0.
Unpaired t test, Mann-Whitney U test, Chi-square test, Fisher’s exact test and logistic
regression model were used appropriately.
Results: Patients with MGD showed higher mean OSDI, TGs, TC, LDL-C, HDL-C as
compared to controls. Dyslipidemia and high lipid parameters were associated with
increasing severity of disease. Increased OSDI, LDL-C ≥130 mg/dl and HDL-C <40 mg/dl
were significantly correlated with MGD in logistic regression model. In other multivariate
logistic regression model , increasing age and MGD were significantly correlated with
dyslipidemia.
Conclusion: Our study showed that symptomatic MGD patients were significantly
associated with dyslipidemia and deranged lipid profile.
