A Comparative Study to determine the Effect of Oral Iron and Parentral Iron Sucrose in the Treatment of Iron Deficiency Anaemia in Pregnant Women

Abstract

Background:To determine the effect of parentral iron sucrose and oral iron in the treatment
of iron deficiency anaemia in pregnant women.Material and Methods:There were two
Category of 45 patients each, with 45 patients in each Category. Category A ladies were
given IV iron sucrose. To restore iron reserves, sucrose was administered at a rate of 10
mg/kg. The whole determined dosage was administered in split doses on alternate days or
twice weekly. For 6 weeks, the women in Category B were given ferrous sulphate as an oral
iron BD. The pills were to be taken on an empty stomach, either two hours before or after a
meal. All initial investigations, including haemoglobin, red blood cell count, reticulocyte
count, PCV, MCHC, serum iron, serum ferritin, and total iron binding capacity of serum,
were completed after six weeks. All haematological markers were checked at the moment of
delivery and again one week afterwards.Results:In the current research, the baseline mean
Hb level in the oral iron treatment Category was 9.11±0.22g/dl and 9.02±0.21g/dl in the
parental iron therapy Category, which was shown to be statistically insignificant between the
Categorys. The Hb level in both the oral and injectable iron Categorys changed significantly
(p<0.05) 6 weeks after commencing the medication. The mean Hb increase in the injectable
iron Category was 3.30 g/dl (p 0.05), and 1.34 g/dl in the oral iron Category (p <0.05).The
increase in serum iron, serum ferritin, and TIBC was also significant (p<0.05) in two
Categorys A and B in our study, whereas the rise in other haematological parameters such as
red cell count, packed cell volume, mean corpuscular haemoglobin concentration, and
reticulocyte counts were non-significant. Indicate that the IV Category outperforms the oral
Category (p<0.05).Conclusion:With no major adverse medication reactions, intravenous iron
sucrose addressed iron deficient anaemia of pregnancy quicker and more efficiently than oral
iron treatment.