Treatment of Nocturia in Patients with Benign Prostatic Hyperplasia Using Desmopressin to Alpha Blockers

Abstract

Background: Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate. It is
a very common urological problem among ageing men and leads to lower urinary tract symptoms. The
aim of the present study was to evaluate the best available medical treatment for nocturia in patients of
BPH. Patients and methods: A prospective study included 44 male patients complaining of LUTs of
BPH with nocturia were enrolled to Urology Department, Zagazig University Hospitals. They were
divided randomly into 2 groups, each group include 22 patients. Group A: the patient received oral
desmopressin add on tamsulosin once daily. Group B, the patient received oral tamsulosin daily. The
clinical assessment was done before and after treatment (12 weeks). Results: No significant difference
founded at before treatment regard total IPSS but group A was significantly lower regard total IPSS
after treatment and both groups significantly decreased after treatment. Group A significantly
associated with better improvement at all 4 domain of sleep scales (Getting to Sleep,Quality of Sleep,
Awake following Sleep and Behavior Following Wakening) more than Group B significant difference
between groups. Conclusion: Oral desmopressin added to α-blockers is well tolerated and beneficial
for improving the IPSS and nocturnal symptoms. Desmopressin can be expected to possess adual
activity when used as an add-on therapy beside α-blockers in reducing nocturia as well as other LUTS.