To Compare The Effect of Magnesium Sulphate And Labetalol In Attenuating Stress Response of Laryngoscopy And Intubation

Abstract

Laryngoscopy and tracheal Intubation are invariably associated with certain
stress responses due to the sympathoadrenal stimulation. These cardiovascular and
neurohumoral alterations may directly affect physiology and increase the risk. So far, various
drugs have been tried but none has been considered ideal for blunting this presser response.
We, therefore, planned this comparative study to evaluate and compare the efficacy of
intravenous magnesium sulfate versus intravenous labetalol in attenuating the presser
response to Laryngoscopy and Tracheal Intubation. Sixty patients, aged 18–50 years,
scheduled for elective surgery under general anaesthesia, at our tertiary care hospital. During
laryngoscopy & intubation, BP rises up to 30-40%, when premedicated with labetalol or
magnesium sulphate, BP rises near to baseline levels and came to baseline level in less time.
Both the drugs prevent the rise in blood pressure and heart rate during laryngoscopy and
intubation but magnesium sulphate is more effective in controlling hemodynamics although it
transiently increases the heart rate in the first minute.