FORMULATION AND IN- VITRO EVALUATION OF METOPROLOL SUCCINATE MATRIX TABLETS

Abstract

The objective of present investigation was to prepare and characterize controlled release (CR) matrix tablets of
Metoprolol Succinate (MS) using polymers like Hydroxy Propyl Methyl Cellulose (HPMC) K100, Carbopol 934, and
Ethocel and also to evaluate different formulation variables like polymers on drug release properties of MS tablets.
HPMC is used as hydrophilic polymer, Carbopol and Ethocel are used as rate controlling polymers. MS tablets were
prepared by employing the wet granulation technique using 2.5% gelatin concentration as binder to achieve prolonged
release of medicaments. The prepared MS tablets were evaluated for hardness, weight variation, FTIR, DSC and drug
release kinetics. Release kinetics were evaluated by using USP Type -II dissolution apparatus. DSC and X- RD studies
confirmed that MS was not in crystalline state. As MS having less half-life (4-6 hrs.) CR tablets are formulated to
enhance half-life of MS tablets and in this research formulation variables are taken from F1 to F17. In vitro drug
content release studies explain that high concentration of polymer will retard the drug release such that there is an
enhancement of half-life of tablet. Among all the formulations F11 having HPMC 25mg, Ethocel 15mg, and Carbopol
25 mg showed maximum drug release (99.85%) in 24 hrs in controlled manner