Development Of Reservoir Type Ketoprofen Transdermal Patches Using Chemical Permeation Enhancers

Abstract

The purpose of the present study was to formulate reservoir type transdermal patches for Ketoprofen (KP) that may
eliminate the potential adverse events that are associated with its oral delivery. Initially, the effect of different
chemical permeation enhancers (Labrasol, Transcutol P, Lauroglycol 90 and Labrafil M 1944 CS at 5% level) on in
vitro KP release from hydro-alcoholic gels was evaluated using Franz diffusion cells. Based on the results obtained
from the permeation studies, suitable permeation enhancers were selected and the reservoir patches of KP were
prepared by loading 2.5% w/w of KP in HPMC (E5) hydro-alcoholic gel with Cotran 9702 and Scotchpak 9733 as
rate controlling and backing membranes respectively. Results from the permeation studies revealed that, among the
permeation enhancers used, Lauroglycol 90 showed superior in vitro KP permeation rates i.e. 12.29 ± 0.29 µg/mL at
the end of 24h, which is 2.58 folds higher compared to control. Overall, the in vitro KP release from the patches was
in the order of Lauroglycol 90 >Labrafil M >Transcutol P >Labrasol. In vitro KP release from the reservoir patches
was evaluated using USP Type V dissolution rate testing apparatus and the results revealed a significant
enhancement in KP release (p<0.05) from patches containing Lauroglycol 90 (1.4 fold) and Labrafil M (1.1 fold)
compared to control. Overall, the results from the present investigation can form basis to perform further ex-vivo
studies that can be useful for the development of an optimised reservoir type transdermal system for KP.