ENHANCEMENT OF RATE OF DISSOLUTION OF ANTI HYPERTENSIVE DRUG (LERCANIDIPINE) BY USING SOLUPLUS AS A CARRIER
DOI:
https://doi.org/10.48047/Keywords:
Lercanidipine, Soluplus, Solid dispersions, Solvent evaporation method.Abstract
Lercanidipine hydrochloride (LER) is a BCS class II antihypertensive drug which results in limited oral
bioavailability of 10%. The purpose of this study is to improve the dissolution and thus the bioavailability of
LER by dispersing it into a hydrophilic polymer. Study involved incorporation of LER in a polymeric matrix a
molecular level. Solid dispersions of LER were prepared by solvent evaporation techniques by varying drug to
polymer ratio. The studies demonstrated that LER solid dispersions show increased solubility and dissolution
rate in comparison with physical mixture and pure drug. Solid dispersion obtained by solvent evaporation
techniques showed improved release compared to pure LER and physical mixture. No interaction of LER and
polymer was confirmed by IR studies. It can be confirmed from the obtained results that solid dispersion can be
a method of choice for increasing the solubility, dissolution and in turn the bioavailability of Lercanidipine
hydrochloride.
