MICROBALOONS: An Incredible Gastro Retentive Drug Delivery System

Abstract

The purpose of writing this review on microballoons is to accumulate the recent literature with a special focus on the
novel technological advancements in floating drug delivery system to achieve gastric retention. Microballoons
(Hollow microsphere) promises to be a potential approach for gastric retention. Microballoons drug-delivery
systems are based on non-effervescent system containing empty particles of spherical shape without core ideally
having a size less than 200 micrometer. Microballoons drug delivery systems have shown to be of better
significance in controlling release rate for drugs having site specific absorption. The floating microballoons
showed gastroretentive controlled release delivery with efficient means of enhancing the bioavailability and
promises to be a potential approach for gastric retention. Optimized hollow microspheres will find the central place
in novel drug delivery, particularly in safe, targeted and effective in vivo delivery promises to be a potential
approach for gastric retention. They aregastroretentive drug-delivery systems, which provide controlled release
properties. The advantages, limitation, methods of preparation of hollow microsphere, applications, polymers
used in hollow microspheres, characterizations of microballoons and formulation aspects with various evaluation
techniques and marketed products are covered in detail.