FORMULATION, EVOLUTION AND OPTIMIZATION OF LERCANIDIPINE HYDROCHLIORIDE ORAL FAST DISSOLVING FILIMS
DOI:
https://doi.org/10.48047/Keywords:
Lercanidipine, Soluplus, Solid Dispersion, Solvent Evaporation Method, HPMC.Abstract
Lercanidipine hydrochloride (LER) is a BCS class II anti hypertensive drug basing on its low solubility and high
permeability characteristics, these drugs having its oral bio availability is dissolution rate limited which results in limited
oral bio availablity of 10%. The purpose of this study is to enhance dissolution and thus the bio availablity of LAR
increases by preparing oral fast dissolving films of LER by solid dispersion technique. The present study involves
incorporation of LER in a polymeric Matrix. Solid dispersions of LER were prepared by box-behnken design through
solvent evaporation techniques by varying drug to polymer ratio. Solubility of LER was studied in different polymers like
Soluplus, Kolliphor, PEG 6000, PVP K30, water, phosphate buffers pH 1.2, 4.5, 6.8. From this study, among all the
solvents and carriers the drug shows high solubility in soluplus and low solubility was seen in water. Films obtained
showed improved LER release compared to pure and physical mixture it can be confirmed from the obtained results that
films can be a method if choice for increasing the solubility dissolution and in turn the bio availability of LER.
