A REVIEW ON THERMOSTABLE VACCINES

Abstract

Vaccines are readily losing their efficacy when exposed to higher temperatures. But 3 vaccines are approved
by World Health Organization for use at temperature up-to 40o
c those are Meningitis, Human Papilo Virus and Cholera
vaccines. Vaccine for SARS–COV–2 is under clinical trial which is also thermostable vaccine. The Indian institute of
sciences and biotech firm developed MYNVAX Vaccine by using genetic engineering.it is a domain of the S–protein of
the SARS -COV–2 viruses called the Receptor binding domain, which attaches itself to the ACE- 2 receptor on the
surface of target cells in the human respiratory tract. This makes the virus to enter the body and cause the infection. The
pseudo viral assays done at the CSIR –Institute of microbial technology in India and the results from the live virus tests
by CSIRO –Australia were very encouraging shows that effective neutralization of alpha, beta, gamma and delta SAR –
COV–2 variants. This review of literature is to summarize the clinical trials, mode of action, storage conditions and
efficacy levels of Thermo stable vaccines.