Development and Optimization of Oral Fast dissolving films of Glibenclamide

Abstract

The objective of the work was to design oral fast dissolving films of a Glibenclamide meant for management of
chronic disease like type-2 diabetes mellitus .Various batches of FDFs were developed by the solvent casting
method using water soluble polymers like Guar gum ,Xanthum gum, Sodium alginate, HPMC K4 as film
formers; Propylene glycol as plasticizers; Sodium starch glycollate as super disintegrating/channeling agent;
Citric acid as salivary stimulating agent ; Sodium saccharin as a sweetener and vanillin as flavouing agent. The
FTIR studies showed that there is no interaction between the drug and polymer The formulation containing drug
with HPMC K4 with propylene glycol as plasticizer showed lowest disintegration time, more uniform and
faster dissolution profile with in 6 minutes with drug release 98.5%, and had better taste, good in stability
studies.