EVALUATION OF ANTI-DIARRHEAL & ANTI-SPASMOLYTIC AND INVITRO ANTI OXIDANT PROPERTIES OF METHANOLIC EXTRACTS OF LANTANA CAMARA AND MYRTUS COMMUNIS

Abstract

Presently, around 25% of medications produced in the globe, are extracted straight from plants or herbs contains
at least one active component. It is acknowledged that the popular of herbal medicines employed as antidiarrheals
have antispasmodic characteristics consequential in delaying gastrointestinal procedures, inhibiting gut motility,
initiating absorption of water and dropping electrolyte discharge in the process, and these biological activities
might explain the benefits of by means of specific herbal medicines in the management and treatment of
diarrhoea. The main aim of the study is to screen Myrtus communis and Lantana camara extracts for their antidiarrheal and anti-spasmodic activity. This study was intended to assess the antidiarrheal activity of the selected
herbs by means of Swiss albino mice models against castor oil stimulated diarrhea, castor oil stimulated
gastrointestinal transit, and castor oil stimulated accumulation of gastrointestinal fluid. In the execution of
antimotility, diarrhea, and anti-secretory agent are seem to be the chief stay agents utilized to drop off the
pathophysiologic circumstances accountable for the progress of diarrhea. The inhibitory force of loperamide on
acetylcholine cause inhibition of discharge intervened with acetylcholine. As an outcome, loperamide lessen every
day fecal volume, reduce fluid and loss of electrolyte, and may perhaps augment viscosity of stool and bulk
density. Coming to the Myrtus communis and Lantana camara, the result of the study verified that the plant
extracts was caused a noteworthy impediment in the onset of diarrhea, reduction in the occurrence of output of
wet fecal and total fecal, along with diminish in the mean weight of wet feces and output of total fecal that were
caused by means of castor oil.. The plants extracts established a noteworthy delay in the onset of diarrhea,
abridged the occurrence of wet feces and also endowed with noteworthy anti-secretory effects at all doses assessed
experimentally. And also, the plants extracts signified the antimotility activity at its higher doses.