PULSATILE DRUG DELIVERY SYSTEMS AND THEIR METHODOLOGIES

Abstract

This review determines introduction to Pulsatile drug delivery system, necessity of PDDS, conditions that demand
PDDS, advantages and disadvantages of PDDS, release pattern, disease that require the PDDS, mechanism of drug
release in PDDS, methodologies to develop the PDD, marketed products and evaluation. PDDS have been attracted
more because they are having multiple benefits over conventional dosage forms and they will deliver the drug at the
right time and in the right amount and thus they are providing spatial and temporal delivery and increasing the
patient compliance. The mechanism of drug release is rapid after welldefined the lag time. A pulse has to be
designed in such a way that a complete and rapid drug release is achieved after the lag time which should match
body’s circadian rhythms with the release of drug which increases the efficacy and safety of drugs by proportioning
their peak plasma concentrations during the 24 hours in synchrony with biological rhythm.These systems are
beneficial for the drugs having chronopharmacological behaviour such as drug used in treatment of rheumatoid
arthritis, osteo arthritis and ankylosing spondylitis like inflammatory disorders. Diseases wherein PDDS are to be
used includes peptic ulcer, asthma, cardiovascular diseases, arthritis, and attention deficit syndrome in children,
cancer, diabetes, and hypercholesterolemia. Therefore Pulsatile drug delivery is one such systems that becametrendy
by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients
suffering from chronic diseases.