Formulation and Characterization of Diltiazem Hydrochloride Oral Fast Dissolving Films
DOI:
https://doi.org/10.48047/Keywords:
Diltiazem HCl, Oral Fast Dissolving Films, Solvent Casting Method and Compatibility.Abstract
The present investigation was aimed with an objective to formulate and evaluate Diltiazem HCl (DTZ) oral fast
dissolving films (OFDFs) to improve convenience and compliance of elderly and pediatric patients. In the present
investigation OFDFs were prepared by using film forming agents like Hydroxyl propyl methylcellulose (HPMC) E15,
HPMC K4M, Methyl cellulose (MC) and Sodium carboxy methyl cellulose (Na CMC), surfactants like Sodium lauryl
sulphate (SLS) and Poly vinyl pyrrolidone (PVP) and Polyethylene glycol (PEG 400) as plasticizer. The OFDFs were
prepared in petri plates employing solvent casting technique. The prepared OFDFs were characterized for DTZ content,
thickness, weight variation, folding endurance and in vitro drug release studies. The compatibility between DTZ and
excipients was confirmed by FTIR in OFDFs. The DTZ OFDFs prepared with HPMC E15 as film forming agent
showed superior DTZ release compared to other film forming agents. The DTZ OFDFs containing PVP showed slight
increased DTZ release compared to OFDFs containing SLS as solubilizing agent. All the prepared OFDFs showed 100
percent cumulative of DTZ release within 30 minutes.
