Environmental Factors Affect Altitude on Coumarin Metabolites Accumulation, Docking Studies, Antiproliferative Activity on Indian Folklore Medicinal Plant Chloroxylon Swietenia Dc

Abstract

In natural plant species, the abiotic parameter height has been shown to influence secondary metabolite elaboration.
To back up this theory, comprehensive chemical and biological research on the leaves of Chloroxylon swieteniaDC,
a strong Indian traditional medicinal plant, have been conducted. C. swietenia leaf samples were gathered at two dist
inct elevations. C. swietenia DC leaves were obtained from the Jaipur woodland region (altitude: 159 meters), The
furano-coumarin metabolites or their precursors were found exclusively in the state of Telangana. The pyaranocoumarin metabolite or its precursors were found exclusively in leaves taken from the Gadchiroli forest area
(altitude: 217 metres) in Maharashtra state. Suberosin analogues and racemosin from the Gadchiroli area are more
active than those from the Jaipur area. Because both furano-coumarins and pyrano-coumarins have been shown to
have anticancer activity in the literature, the isolated compounds of C. swietenia was subjected to antiproliferative
screening against some human cancer cell lines in order to identify potent lead compounds, as well as docking
studies, i.e. 5ZSY (lung cancer) (-6.6).