A comprehensive knowledge on the Aquasome novel drug delivery system

Abstract

Aquasomes are nanoparticles but being a simple nanoparticles these are 3 layer self-assembled structures
comprised of a solid phase nano-crystalline core coated with an oligometric film to which biochemically active
molecules are adsorbed with or without modification.The aquasomes are made up of ceramic core which are
stabilised by carbohydrates and by using methods like co-polymerisation, diffusion or adsorption, the
pharmacologically active molecules were incorporated on to the carbohydrates surface of the nanoparticles
which are preformed. Aquasomes were evaluated by transmission electron microscopy, scanning electron
microscopy for the morphology and size distribution. Aquasomes are 3 layered, self assembled particulates used
in nano-therapeutics. They are useful in delivery of various drug molecules which are biologically active.
They are used as vaccines for delivery of viral antigen, insulin delivery in treating the diabetes, enzyme
transporter like DNAase. Aquasomes as blood substitutes, haemoglobin immobilized on oligomer surface
because of release of oxygen by haemoglobin in sensitive conformation. It is also used in gene therapy.