Evaluation of Anti-alzheimer activity of Methanolic extract of leaves of Jatropha gossypifolia in ICV Amyloid-β Alzheimer’s model

Abstract

The aim of this study was to evaluate the anti-alzheimer activity of methanolic extract of leaves of Jatropha
gossypifolia in ICV Amyloid-β Alzheimer’s disease model. The leaves of Jatropha gossypifolia
(Family:Euphorbiaceae) extracted with methanol and studied by in vivo Aβ1-42 induced model in rats. In vivo
behavioural study results showed decreased RME, CWME and IWME in cognitive declined rats in RAM
indicates the cognitive enhancement potential of the plant extracts. Also reduced the IL and STL period in Aβ1-
42 infused rat evidences the cognitive enhancement activity of above extracts in Alzheimer’s like pathology.
Met-L-JG in Aβ1-42 infused rats have shown significant decrease in LPO, NO, and Increased the level of SOD,
GSH, and CAT represents the anti-oxidant activity of the extract in Alzheimer’s by in -vivo. Met-L-JG has
drastically attenuated the brain TNF-α and IL-1β levels in the Aβ1-42 treated rats represent the antineuroinflammatory activity of the extract in Alzheimer’s. Met-L-JG (200 mg/kg) reduced the hippocampal
glutamate level in comparison to Aβ1-42 infused rats indicates the anti-excitotoxicity capacity of above extract in
neurodegenerative conditions like Alzheimer’s disease. Histopathological studies showed that met-L-JG (100
mg/kg), met-L-JG (200 mg/kg) have reduced the neuronal damage with decreased necrotic, swelling and
neuronal degeneration with restored intact cells which are comparable with SO group. In the view of above
results we concluded that methanolic extracts of leaves of Jatropha gossypifolia were showed to be potent antialzheimer’s in experimental animals.