Investigation of Anti-Parkinsonian Effect of Benincasa hispida Fruit Juice on Haloperidol Induced Experimental Animal Model
DOI:
https://doi.org/10.48047/Keywords:
Benincasa hispida, Catalepsy, Metal bar, Haloperidol, Syndopa.Abstract
The objective of the study is to investigate the anti parkinson’s activity of Benincasa hispida fresh fruit juice on
experimental animal model.In rats, catalepsy was induced using haloperidol (1 mg/kg i.p.). Treatment groups
received syndopa (10 mg/kg) and BHFFJ at the dose of (100, 200, and 400 mg/kg) orally. Behavioral changes were
assessed by carrying out catalepsy by bar test, muscle relaxant test by rotarod, and locomotor activity by
actophotometer. Biochemical parameters were also assessed by carrying out Assay of dopamine and catalase.
Syndopa and BHFFJ treated groups showed a significant difference in behavioral and biochemical parameters as
compared to haloperidol control group in the experimental models.BHFFJ exhibited significant antiparkinsonian
activity in haloperidol rat model.
