Thyroid function hormones profile in acute stroke patients

Abstract

Objectives: This study carried out to estimate the correlation of serum thyroid hormones
concentration with clinical characteristic and effective short term outcome in patient following
severe ischemic stroke. Outcome in a tertiary care hospital in Cairo.
Methods: n the current descriptive (cross-sectional) investigation we tried to demonstrate the
correlation between the difference in thyroid pattern and acute ischemic stroke in 101 cases that
were approved to Nasser Institute Hospital within two days of the event between from May 2019
to November 2019 with follow up after 30 days of discharge from hospital. Inclusion and
exclusion criteria were strictly exercised. National Institute of Health Stroke Scale (NIHSS) and
modified Rankin scale (mRS) score was noted. Thyroid function hormones (TSH, T3, T4) were
estimated from blood. Patients were stratified into 6 groups: euthyroid, nonthyroidal illness
syndrome (NTIS), subclinical hyperthyroid, hyperthyroid, subclinical hypothyroid, and
hypothyroid. Clinical, functional, and radiological evaluation were done for the patients.
Statistical SPSS 20.0 software and Microsoft excel were used for statistical analysis (P ≤ 0.05).
Results: A total of 101 stroke cases were thus included in the study comprising 57 males and 44
females. The mean age of patients was 18-80 [63.6 ± 12.4] years. Of the 101 patients 75.2%
were euthyroid, 16.8% were nonthyroidal illness syndrome (NTIS),3.96% were subclinical
hyperthyroid,0.99%were hyperthyroid, 0.99% were subclinical hypothyroid, and 1.98%were
hypothyroid. Univariate analysis shows serum T3 was inversely associated with NIHS score
after 30 days of discharge from hospital. Multivariate analysis shows significant correlation
between nonthyroidal illness syndrome and NIHS score and mRS on day o of onset and after 30
days of discharge and also shows inversely association between T3 and NIHS score and mRs
after 30 days of discharge from hospital.
Conclusion: Non thyroidal illness syndrome had influence to degree of stroke severity, degree of
disability and functional outcome. Serum T3 levels had a negatively correlation with NIHSS
score and modified Rankin scale. Low serum T3 levels associated with poor prognosis in acute
ischemic stroke patients.