Evaluation of serum lipid profile and ABO blood groups in oral cancer and tobacco associated oral lesions among Sriganganagar Population; A Case control study

Abstract

Introduction: Oral cancer (OC) is among the major cause of morbidity and mortality in India and is mostly
preceded by clinically definable premalignant lesion and/or conditions. Role of alterations in serum lipid profile in
oral cancer and the incidence of OC in various blood groups remain controversial.
Aims and objectives: To evaluate and compare the variations in serum lipid profile (total cholesterol, total
triglycerides, low density lipoproteins, very low density lipoproteins, high density lipoproteins) and ABO/Rh blood
groups in oral cancer and tobacco associated oral lesion Materials and methods: Thirty patients with OC (Group
1), 30 patients with tobacco related lesions (Group 2), 30 tobacco abusers (TAs) with no lesions (Group3), and 30
age and gender matched healthy controls (Group 4) were included in the study. Serum lipid profile including total
cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), Very low density lipoprotein
(VLDL), and triglycerides (Tg) were evaluated in each patient using a semiautomatic autoanalyzer STAT fax-3300
Ark Diagnostics and the blood group of the patients was determined by placing a drop of blood on the slide and
treating with anti-A, anti-B and Anti-Rh sera. Difference in lipid profile and blood groups in various groups was
determined.
Results: LDL was lower and HDL was higher in group1 as compared to group 4. The mean TC in group 3 was
more than the Group1 and Group 2. The mean VLDL was also more in Group 3. No significant correlation was
found in the prevalence of ABO/Rh blood group in study Group.Conclusion: There was no significant relation
between lipid profile and ABO Rh blood Groups in oral cancer and tobacco associated oral lesion patients.