Effects Of Direct Acting Antivirals on Glomerular Filtration Rates and Neutrophil Gelatinase-Associated Lipocalin During Treatment of Hepatitis C Patients
DOI:
https://doi.org/10.48047/Keywords:
Antiviral agents; Hepatitis C virus; Inflammation; Neutrophil Gelatinase-Associated Lipocalin Protein; Kidney Tubule; Sofosbuvir; Paritaprevir; Acute Kidney InjuryAbstract
Background
Direct acting antivirals (DAA) havesignificantly contributed to the treatment protocol for chronic hepatitis C (CHC),
nonetheless, there are concerns regarding their safety especially in patients with chronic kidney disease (CKD).
Neutrophil gelatinase-associated lipocalin (NGAL) is an emerging biomarker for renal tubular injury. Herein, we
aimed to estimate the changes in serum NGAL levelsfollowing DAA-therapy, as well as to investigate the diagnostic
reliability of serum NGAL in case of potential DAA-related nephrotoxicity. We consecutively enrolled 80treatmentnaïve adult CHC patients who were eligible for DAA-therapy. We further categorizedthe patients into 2 groups,
group I included 40 patients with normal kidney functions who received SOF/DAC for 12-weeks, whereas group II
included 40 CKD patients who received OBV/PTV/r + RBV for 12-weeks. In addition, 20 healthy participants with
matched age and sex were enrolled as controls.The serum NGAL level was measured at baseline and at the end of
therapy(EOT) using an Enzyme-Linked Immunosorbent Assay (ELISA).
