Effect of Gingko Biloba and Onion Juice on xanthine oxidase enzyme and renal function in induced hyperuricemic rats

Abstract

The present study was conducted to evaluate the role of some natural safe source plants on the hyperuricemia in
ratsusing Ginkgo biloba leaf extract and onion juice against hyperuricemia in induced hyperuricemic rats using
potassium oxonate as an inducing agent. 40 Sprague Dawleystrain, mean weighting 80-110 g were used, albino rats
were categorized into 4 equal groups as follows:
Group GI: Control group: Only given basal diet, Group GII: Given basal diet plus 6.6 mg/kg/day plus potassium
Oxonate. GIII: Co-treated group in which, rats were received basal diet, 6.6 mg/kg/day potassium oxonate plus
gingko biloba leaf extract 80 mg/kg body weight.Group GIV: Co-treated group in which, rats were received basal
diet, 6.6 mg/kg/day potassium Oxonate plus 10 mg /kg of onion
At the end of 4 weeks, blood samples were collected and sera were separated and analyzed for determination of
serum XO activities, UA , urea and creatinineconcentrations also the kidney specimens were removal for
histopathological examination.
The obtained results were statistically analyzed and represented in 1 table, 1 figure and 4 photos. The general
findings can be summarized as follows:
PO caused hyperuricemia and increment in serum XO ,uric acid urea and creatinine, caused various degrees of
pathological damages in kidneys.
There is a high significant difference of uric acid, urea and creatinine from potassium oxonate (GII) compared with
control group (GI), co treated potassium oxonate with onion group(GIV) and co treated potassium oxonate with
ginkgo biloba (GIII) at p˂0.00. kidneys of rat received potassium oxonate showing inflammatory cells infiltration
inside and in between destructed renal tubules. kidneys of rat received potassium oxonate and gingko biloba
showing minimal tissue reaction. kidneys of rat received potassium oxonate and onion showing degeneration and
necrosis in some of tubular epithelium.