Serum Levels of Intercellular Adhesion Molecule-1, N-Terminal pro-Brain Natriuretic Peptide and Cardic Troponin-I among Haemodialysis Patients with Hepatitis C Virus

Abstract

Background: Chronic hepatitis C virus infection is a global health burden that has been associated with many diseases, including
coronary artery disease.
Objectives:Determine the risk of coronary artery disease among haemodialysis patients through the measuring endothelial and
cardiac biomarkers in their serum.
Methodology:Measurement the levels of intercellular adhesion molecule-1 (endothelial function biomarker), N-terminal pro-brain
natriuretic peptide and cardic troponin-I(cardiac dysfunction biomarkers) in the serum of 45 Iraqi patients on haemodialysis
infected with hepatitis C virus (patients group), as well as their control group (45 Iraqi patients on hemodialysiswithout hepatitis C
virus infection) by the using of Enzyme linked immunosorbent assay technique.
Results:Elevated serum levels of all the above mentioned biomarkers were seen in the patients group in comparison to the control
group. Strong positive correlations were found between intercellular adhesion molecule-1 biomarker with bothcardiac dysfunction
biomarkers (cardictroponin-I and the N-terminal pro-brain natriureticpeptide)among the patients group. Another positive
correlation was revealed between the cardiac dysfunction biomarkers themselves among the patients group.
Conclusions:Patients with hepatitis C virus infection have an increased risk of cardiovascular diseases. The findings of this study
indicate the importance of regular screening of such important biomarkers among patients with haemodialysis in order to prevent
the risk of such complications.