Design, Synthesis and Biological Evaluation of Some New Piperazine Associated Hydrazone Derivatives

Abstract

A new series o of compound 2-{4-[(4-Chloro-cyclohexyl)-cyclohexyl-methyl]-piperazin-1-
yl}-ethoxy)-acetic acid cyclohexyl-methylene-hydrazide derivatives synthesized by the
reaction of CetirizineHCl( 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-
yl}ethoxy)acetic acid dihydrochloride ) with H2SO4 and ethanol followed by esterification
reaction in the presence of hydrazine hydrate to give (2-{4-[(4-Chloro-cyclohexyl)-
cyclohexyl-methyl]-piperazin-1-yl}-ethoxy)-3-methyl-pentan-2-one and its rection with
cyclohexane carbaldehyde finally yield compound 2-{4-[(4-Chloro-cyclohexyl)-cyclohexylmethyl]-piperazin-1-yl}-ethoxy)-acetic acid cyclohexyl-methylene-hydrazide with its
substituted derivative 4-dimethylamino- benzaldehyde. The compound was demonstrated for
in vivo antidepressant activity by tail suspension test on Swiss albino mice. Compound was
characterized by 1HNMR along with molecular docking studies. On the basis of evaluations
compound have shown significant antidepressant activity as compared to the standarddrugs.