A STUDY OF NOVEL CARDIAC BIOMARKERS FOR CARDIOVASCULAR DISEASE DETECTION
DOI:
https://doi.org/10.48047/Keywords:
Cardiac biomarkers, growth differentiation factor-15, high-sensitivity troponin, soluble ST2.Abstract
Introduction: The effectiveness of biomarkers in predicting cardiovascular events in
community-based populations has been inconsistent, often failing to provide additional
information beyond standard risk factors. Many previously studied biomarkers lack
cardiovascular specificity.
Materials and Methods: To evaluate the predictive value of three novel biomarkers induced
by cardiovascular stress, soluble ST2, growth differentiation factor-15, and high-sensitivity
troponin I, we measured them in 134 participants. Using multivariable-adjusted proportional
hazards models, we assessed the individual and combined ability of these biomarkers to predict
adverse outcomes. Additionally, we created a "multimarker" score comprising the three
biomarkers along with B-type natriuretic peptide and high-sensitivity C-reactive protein.
