A Comparative Study to Evaluate Efficacy of IV Infusion of Dexmedetomidine versus IV Infusion of Propofol for Post-Operative ICU Sedation: An Original Research

Abstract

Objective: This study aimed to compare the efficacy and safety of intravenous (IV) infusion 
of dexmedetomidine versus IV infusion of propofol for post-operative sedation in the 
intensive care unit (ICU).
Methods: A prospective, randomized controlled trial was conducted involving 300 postoperative ICU patients. Patients were randomly assigned to receive either dexmedetomidine 
or propofol for sedation. Sedation depth was assessed using the Richmond Agitation-Sedation 
Scale (RASS), monitoring vital signs, and adverse events. Baseline demographic data, 
including age, sex, BMI, comorbidities, surgery duration, and APACHE II scores, were 
recorded. Statistical analysis employed t-tests, chi-square tests, and Fisher's exact tests for 
comparison.