Carbamylated hemoglobin levels in hemodialysis patients in Indian population

Abstract

Background:Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present
for > 3 months. The present study was conducted to assess the CarbamylatedHemoglobin levels in patients on
Hemodialysis in Indian population and to see its correlation with urea, creatinine, albumin, bicarbonate and their
comparison with healthy population.
Materials & Methods:Present study was conducted in Dr. D.Y. Patil Medical College Hospital and Research
Center, Pune, Maharashtra in Department of Nephrology who were on maintenance hemodialysis for > 3 months
duration without any active infection who were willing to consent and were enrolled in the study. Of 25 patients
with chronic kidney disease on maintenance hemodilaysis were divided into two groups and one healthy control
group was taken. Group – I: CKD patients on weekly twice haemodialysis. Group – II: CKD patients on weekly
thrice haemodialysis. Group – III: Included 10 healthy volunteers as controls.Access details of the patients and the
dialysis details of the dialysis sessions at baseline were recorded.CarbamylatedHemoglobin (CHb) checked at
baseline. Kt/V assessed at baseline average Kt/V was calculated and compared with healthy controls.
Results: Patients were in age group between 18-20yrs (2patients), 21-30yrs (5patients), 31-40yrs (3patients),
41-50yrs (5patients), 51-60yrs (5patients), 61-70yrs (4patients), 71-80yrs (1patient). There were 19 (76%) and 6
females (24%) and there were 10 healthy controls. The mean age was 44.16 years, BMI was 22.06Kg/m2, Hb
was 7.62gm/dl, blood urea was 114.48mg/dl, Sr Cr was 9.24mg/dl, serum Na (mmol/l) was 141.60, serum
K(mmol/l) was 4.83, serum albumin(gm/dl) was 2.94, Ph was 7.32, HCO3 was 17.94, iPTH (pg/ml) was 184.49,
Kt/V was 1.26, Valinehydantoin absorbance at 570nm was 0.67, CHb (ug/gmHb) was 89.99 and blood flow rate
(ml/min) was 324.
Conclusion:Carbamylated haemoglobin had a direct correlation with blood urea nitrogen levels and with serum
creatinine levels in chronic kidney disease patients on maintenance haemodialysis compared to healthy controls.