CLINICAL SPECTRUM OF DENGUE IN CHILDREN AND CORRELATION OF ITS SEVERITY WITH COAGULATION PROFILE AND PLATELET COUNTAN ORIGINAL RESEARCH
DOI:
https://doi.org/10.48047/Keywords:
Dengue, Fever, IgM, IgG, International Normalized Ratio [INR], NS-1, Thrombocytopenia.Abstract
Background: Dengue fever is an acute febrile infectious disease in subtropical and tropical areas that is
progressively making its way from being “one of the great neglected diseases of mankind” towards being
acknowledged as one of the world’s major infectious diseases.
Aim: The aims of the study were to study the clinical manifestation of patients with dengue fever along with
various laboratory parameters in patient with dengue fever.
Methods: This is a prospective observational study will be conducted at Department of Paediatrics of a
tertiary care centre. The study was conducted between October 2016 and September 2018 on50 patients
between the age group 0-18 years and a confirmed diagnosis of dengue fever. The study included consents by
parents/guardian, data collection by meticulous history talking and clinical examination, appropriate
investigations followed by statistical correlations.
Results: In our study incidence rate of dengue was 29.8% and prevalence was 2.9 %. The most common age
group amongst study population wasmore than 10 years (36%) followed by 6 to 10 years (34 %) and 1 to 5
years (24%). There was male predominance (56%) as compared to female (44%). Fever was the most common
clinical features observed amongst study population followed by Nausea (62%) and headache (42%) On general
examination, high grade fever, Low grade fever, Pallor and Tachycardia was present in 48%, 52%, 8% and 36%
of study population respectively. TLC was deranged in 80 % of dengue cases. SGPT deranged was deranged in
28 % of dengue cases. Sixty six percent of the study population had Platelet count of< 1.5 lakh and 34% had >
1.5 lakh. PT, INR and PTT was observed deranged in 8%, 6 % and 12 % of study population respectively.
Conclusion: Most of the dengue cases were diagnosed by NS 1 followed by IgM and IgG. Leucopoenia,
deranged coagulation profile and thrombocytopenia were associated with sever dengue infection
