Evaluation of Efficacy of Platelet Rich Plasma as a Scaffold in Regenerative Endodontic Treatment: An In-Vivo Study.

Abstract

Background: In the past years, there has been several discoveries regarding regenerative
endodontics Studies conducted in the past showed that platelet concentrates can be used as a
scaffold for regeneration. These platelet concentrates can be easily prepared in dental
environment, are autologous and are high in growth factors like transforming growth factor,
platelet derived growth factor and endothelial growth factor. The present study was
conducted with the aim to determine PRP as a scaffold in regenerative endodontics.
Materials and methods:
The study was conducted in the Department of dentistry at the institute. The study included
immature single rooted teeth that required root canal treatment. Teeth were randomly divided
into two groups- group I received PRP and Group II received blood clot. Triple antibiotic
powder (metronidazole, cefalor, ciprofloxacin) was placed. Subjects were recalled after 3
weeks for the resolution of symptoms and the triple antibiotic powder was placed again.
Vitality was assessed, and the radiographs were taken to determine apical closure and
periapical healing. Radiographic root area was measured preoperatively and postoperatively
by a trained radiologist who was blinded. All the data was arranged in a tabulated form and
analyzed statistically using SPSS software.
Results: The mean age of the subjects was 10.24 years. There were 12 males (60%) and 8
females (40%) in the study. Mean first preoperative reading was 18.35+/-3.23. Mean second
preoperative reading was 18.30+/-3.21. There were 50% teeth in Group I and 20% teeth in
Group II that showed positive response to vitality tests. Conclusion: Platelet rich plasma are a useful scaffold material for regenerative endodontics,
it favorably lead to apical closure and positive vitality test.