COMPARISON OF EFFECT OF PREOPERATIVE INTRASAL DESMOPRESSIN AND INTRAVENOUS DESMOPRESSIN ON INTRAOPERATIVE BLEEDING DURING FESS FOR CHRONIC RHINOSINUSITIS: 1 YEAR RANDOMIZED CONTROL STUDY

Abstract

Surgeons face a challenge to surgical field quality when functional endoscopic sinus surgery causes
bleeding. The purpose of this research was to examine the relationship between desmopressin
premedication and endoscopic sinus surgery complications, namely blood loss and surgical field
quality. Ninety patients with chronic sinusitis who met the physical status I or II criteria set by the
Indian Society of Anesthesiologists received endoscopic sinus surgery. Before the procedure, they
were given saline or desmopressin 0.3 μg/kg at random. Propofol and remifentanil infusions were
used to manage the anaesthesia, while mild and controlled hypotension was maintained. Following
surgery, the surgeon checked the operative field for quality and blood loss. We looked at how
desmopressin affected hemodynamic factors and anaesthetic needs. The desmopressin group had a
much lower blood aloss compared to the control group. Compared to the control group, the
desmopressin group had surgeons who were more happy with the surgical field. The desmopressin
group had reduced remifentanil and esmolol requirements compared to the control group. To
successfully decrease bleeding during endoscopic sinus surgery, 0.3 μg/kg of desmopressin may be
used before the procedure.